[HTML][HTML] Oxidative stress-based therapeutics in COPD

PJ Barnes - Redox biology, 2020 - Elsevier
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

Targeting oxidative stress in central nervous system disorders

M Patel - Trends in pharmacological sciences, 2016 - cell.com
There is widespread recognition that reactive oxygen species (ROS) play key roles in
normal brain function and pathology in the context of neurological disease. Oxidative stress …

Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024 - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy

P Kirkham, I Rahman - Pharmacology & therapeutics, 2006 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory lung diseases
that are characterized by systemic and chronic localized inflammation and oxidative stress …

Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy

VL Kinnula, CL Fattman, RJ Tan… - American journal of …, 2005 - atsjournals.org
Idiopathic ulmonary fibrosis (histopathology of usual interstitial pneumonia) is a progressive
lung disease of unknown etiology. No treatment has been shown to improve the prognosis …

Mitochondria-targeted peptide antioxidants: novel neuroprotective agents

HH Szeto - The AAPS journal, 2006 - Springer
Increasing evidence suggests that mitochondrial dysfunction and oxidative stress play a
crucial role in the majority of neurodegenerative diseases. Mitochondria are a major source …

Targeting the redox balance in inflammatory skin conditions

FA Wagener, CE Carels, DMS Lundvig - International journal of molecular …, 2013 - mdpi.com
Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal
physiological conditions, ROS production is tightly regulated, and ROS participate in both …

Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis

I Grattagliano, VO Palmieri, P Portincasa… - The Journal of nutritional …, 2008 - Elsevier
Although the biochemical steps linking insulin resistance with the metabolic syndrome have
not been completely clarified, mounting experimental and clinical evidence indicate …

Catalase and glutathione peroxidase mimics

BJ Day - Biochemical pharmacology, 2009 - Elsevier
Overproduction of the reactive oxygen species (ROS) superoxide (O2−) and hydrogen
peroxide (H2O2) are increasingly implicated in human disease and aging. ROS are also …

Neurotoxicity evoked by organophosphates and available countermeasures

L Pulkrabkova, B Svobodova, J Konecny… - Archives of …, 2023 - Springer
Organophosphorus compounds (OP) are a constant problem, both in the military and in the
civilian field, not only in the form of acute poisoning but also for their long-lasting …