NMR spectroscopy for metabolomics research

AH Emwas, R Roy, RT McKay, L Tenori, E Saccenti… - Metabolites, 2019 - mdpi.com
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …

JL Wolfender, JM Nuzillard, JJJ Van Der Hooft… - Analytical …, 2018 - ACS Publications
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …

The role of natural product chemistry in drug discovery

MS Butler - Journal of natural products, 2004 - ACS Publications
Although traditionally natural products have played an important role in drug discovery, in
the past few years most Big Pharma companies have either terminated or considerably …

Metabolomics: current analytical platforms and methodologies

WB Dunn, DI Ellis - TrAC Trends in Analytical Chemistry, 2005 - Elsevier
During the previous decade, a new array of analytical methodologies and technologies were
introduced related to the analysis of microbial, plant and animal metabolomes (complete …

Beyond the paradigm: Combining mass spectrometry and nuclear magnetic resonance for metabolomics

DD Marshall, R Powers - Progress in nuclear magnetic resonance …, 2017 - Elsevier
Metabolomics is undergoing tremendous growth and is being employed to solve a diversity
of biological problems from environmental issues to the identification of biomarkers for …

Advances in structure elucidation of small molecules using mass spectrometry

T Kind, O Fiehn - Bioanalytical reviews, 2010 - Springer
The structural elucidation of small molecules using mass spectrometry plays an important
role in modern life sciences and bioanalytical approaches. This review covers different soft …

Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants

C Lankatillake, T Huynh, DA Dias - Plant Methods, 2019 - Springer
Abstract Type 2 Diabetes Mellitus has reached epidemic proportions as a result of over-
nutrition and increasingly sedentary lifestyles. Current therapies, although effective, are not …

Plant-derived compounds in clinical trials

A Saklani, SK Kutty - Drug discovery today, 2008 - Elsevier
Plants remain an important source of new drugs, new drug leads and new chemical entities.
The plant-based drug discovery resulted mainly in the development of anticancer and anti …

Combined nuclear magnetic resonance spectroscopy and mass spectrometry approaches for metabolomics

MPM Letertre, G Dervilly, P Giraudeau - Analytical chemistry, 2020 - ACS Publications
Metabolomics is based on cutting-edge analytical methods that provide a “snapshot” of all
the detectable metabolites, small molecules generally weighing under 1200 Da, present in …

Cryogenically cooled probes—a leap in NMR technology

H Kovacs, D Moskau, M Spraul - Progress in Nuclear Magnetic Resonance …, 2005 - Elsevier
During the 50 years of NMR, the technology has renewed itself again and again although
the basic physical principles remain the same. As technical advances and novel materials …