Cell-free DNA (cfDNA) refers to short fragments of acellular nucleic acids detectable in
almost all body fluids, including blood, and is involved in various physiological and …

Cancer is a leading cause of death in the world. Increasing evidence has demonstrated that
early diagnosis holds the key towards effective treatment outcome. Cancer biomarkers are …

An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …

Transformation of a normal cell to a malignant one requires phenotypic changes often
associated with each of the initiation, promotion and progression phases of the carcinogenic …

Circulating cell-free DNA (cfDNA) has been suggested as a cancer biomarker. Several
studies assessed the usefulness of quantitative and qualitative tumor-specific alterations of …

Colorectal cancer is one of the major causes of cancer‐related death in the Western world.
Patient survival is highly dependent on the tumor stage at the time of diagnosis. Reduced …

Aberrant DNA methylation has shown promise as a biomarker for the early detection of
cancer. To discover novel genes frequently methylated at an early stage in colorectal cancer …

DNA methylation-based epigenetic signatures have become valuable cancer biomarkers.
We highlight the advantages of liquid biopsy based DNA-methylation profiling for …

Ovarian cancer (OC) causes significant morbidity and mortality as neither detection nor
screening of OC is currently feasible at an early stage. Difficulty to promptly diagnose OC in …

Background Colorectal cancer (CRC) screening is the most efficient strategy to reduce
disease-related mortality. Frequent aberrant DNA methylation is known to occur in selected …