Transcriptional deregulation is one of the core tenets of cancer biology and is underpinned
by alterations in both protein-coding genes and noncoding regulatory elements. Large …

Cancer is fueled by the aberrant activity of oncogenic and tumor suppressive pathways.
Transcriptional dysregulation of these pathways play a major role both in the genesis and …

Super-enhancers are important for controlling and defining the expression of cell-specific
genes. With research on human disease and biological processes, human H3K27ac ChIP …

Super-enhancers (SEs) in a broad range of human cell types are large clusters of enhancers
with aberrant high levels of transcription factor binding, which are central to drive expression …

Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are 2 well-defined
entities that diverge in their basic pathogenic mechanisms and clinical evolution but they …

Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with
transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote …

Estimating familial cancer risks is clinically important in being able to discriminate between
individuals in the population at differing risk for malignancy. To gain insight into the familial …

Super-enhancers (SEs) consist of a cluster of many enhancers bound to a great number of
transcription factors. They are critical cis-regulatory elements that determine the identity of …

Genome-wide association studies (GWAS) have advanced our understanding of
susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of …

Summary PD-L1 and PD-L2 are important targets for immune checkpoint blockade, but how
tumor cells achieve their expression remains to be addressed. Here, we find that PD-L1 and …