The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

Mild cognitive impairment (MCI) is a common trait of Parkinson's disease (PD), often
associated with early motor deficits, eventually evolving to PD with dementia in later disease …

Alzheimer's disease (AD) is the most common cause of dementia. Despite intensive
research efforts, there are currently no effective treatments to cure and prevent AD. There is …

L-type amino acid transporter 1 (LAT1)-specific ligands and polyion complexes are used as
brain-specific targets to deliver RNA-based drugs across the blood-brain barrier. We …

Membrane transporters playing an important role in the passage of drugs, metabolites and
nutrients across the membranes of the brain cells have been shown to be involved in …

Alzheimer's disease (AD) is the most common neurodegenerative disorder. AD hallmarks
are extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles in the brain …

As a dietary strategy, methionine restriction has been reported to promote longevity and
regulate metabolic disorders. However, the role and possible regulatory mechanisms …

Background Blood-brain barrier (BBB) models based on primary murine, bovine, and
porcine brain capillary endothelial cell cultures have long been regarded as robust models …

Background: Disturbed metabolism has been proposed as being involved in the
pathogenesis of Alzheimer's disease (AD), and more evidence from human AD brains is …

The blood–brain barrier (BBB) formed by the brain capillary endothelial cells with its tight
junctions, membrane transporters, and metabolizing enzymes plays an important role in …