Kaposi sarcoma

E Cesarman, B Damania, SE Krown, J Martin… - Nature reviews Disease …, 2019 - nature.com
Kaposi sarcoma (KS) gained public attention as an AIDS-defining malignancy; its
appearance on the skin was a highly stigmatizing sign of HIV infection during the height of …

Virus-like particles as preventive and therapeutic cancer vaccines

AL Tornesello, M Tagliamonte, FM Buonaguro… - Vaccines, 2022 - mdpi.com
Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the native
virus structure without being infectious. VLPs, similarly to wild type viruses, are able to …

KSHV (HHV8) vaccine: promises and potential pitfalls for a new anti-cancer vaccine

C Casper, L Corey, JI Cohen, B Damania, AA Gershon… - npj Vaccines, 2022 - nature.com
Seven viruses cause at least 15% of the total cancer burden. Viral cancers have been
described as the “low-hanging fruit” that can be potentially prevented or treated by new …

Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents

L Zhong, W Zhang, C Krummenacher, Y Chen… - Trends in …, 2023 - cell.com
Herpesviruses are among the most successful viruses found in human populations. They
establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry …

Co-infection of the Epstein–Barr virus and the Kaposi sarcoma-associated herpesvirus

M Böni, L Rieble, C Münz - Viruses, 2022 - mdpi.com
The two human tumor viruses, Epstein–Barr virus (EBV) and Kaposi sarcoma-associated
herpesvirus (KSHV), have been mostly studied in isolation. Recent studies suggest that co …

A pentavalent Epstein-Barr virus-like particle vaccine elicits high titers of neutralizing antibodies against Epstein-Barr virus infection in immunized rabbits

GM Escalante, J Foley, LZ Mutsvunguma, E Rodriguez… - Vaccines, 2020 - mdpi.com
Primary infection with Epstein-Barr virus (EBV) is associated with acute infectious
mononucleosis, whereas persistent infection is associated with chronic diseases such as …

Immunization of mice with virus-like vesicles of Kaposi Sarcoma-associated herpesvirus reveals a role for antibodies targeting ORF4 in activating complement …

AK Lam, R Roshan, W Miley, N Labo, J Zhen… - Journal of …, 2023 - Am Soc Microbiol
Infection by Kaposi sarcoma-associated herpesvirus (KSHV) can cause severe
consequences, such as cancers and lymphoproliferative diseases. Whole inactivated …

A multivalent Kaposi sarcoma-associated herpesvirus-like particle vaccine capable of eliciting high titers of neutralizing antibodies in immunized rabbits

DH Mulama, LZ Mutsvunguma, J Totonchy, P Ye… - Vaccine, 2019 - Elsevier
Kaposi sarcoma-associated herpesvirus (KSHV) is an emerging pathogen and the causative
agent of multiple cancers in immunocompromised patients. To date, there is no licensed …

Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine …

WS Yang, D Kim, S Kang, CJ Lai, I Cha, PC Chang… - mBio, 2024 - journals.asm.org
Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 is an etiological
agent of Kaposi's Sarcoma, multicentric Castleman's disease, and primary effusion …

The Kaposi's sarcoma-associated herpesvirus (KSHV) gH/gL complex is the predominant neutralizing antigenic determinant in KSHV-infected individuals

Y Mortazavi, SJ Lidenge, T Tran, JT West, C Wood… - Viruses, 2020 - mdpi.com
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's
sarcoma (KS), one of the most prevalent cancers of people living with HIV/AIDS in sub …