In the context of the structural complexity necessary for a molecule to selectively display a
therapeutical action and the requirements for suitable pharmacokinetics, a robust synthetic …

Behavioural and psychological symptoms of dementia (BPSD) are presented in 95% of
Alzheimer's Disease (AD) patients and are also associated with neurotrophin deficits. The …

Background and Purpose The development of effective therapeutic strategies against
Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor ligands have a …

Pearls have been used in traditional Chinese medicine for the treatment of myopia, epilepsy,
and palpitations. We previously demonstrated that the intraperitoneal administration of nacre …

Recent evidence suggests that I2-imidazoline ligands have neuroprotective properties in
animal models of neurodegeneration, such as Alzheimer's disease (AD). We recently …

In searching for novel targets to design antidepressants, among the characterized
imidazoline receptors (IR), I2 receptors are an innovative therapeutical approach since they …

Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer's
disease (AD) being the most dominant, without efficacious drugs, and with only a few …

Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and
previous studies showed that regulation of I2R signaling has neuroprotective potential. In …

Recent studies pointed out the modulation of imidazoline I 2 receptors (I 2-IR) by selective
ligands as a putative strategy to face neurodegenerative diseases. Foregoing the classical 2 …

The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind
due to their vast prevalence and the lack of efficacious treatments. In this scenario, we …