The three subsets of human monocytes, classical, intermediate, and nonclassical, show
phenotypic heterogeneity, particularly in their expression of CD14 and CD16. This has …

Background Sargramostim [recombinant human granulocyte-macrophage colony-
stimulating factor (rhu GM-CSF)] was approved by US FDA in 1991 to accelerate bone …

The mononuclear phagocyte system (MPS) is a family of cells including progenitors,
circulating blood monocytes, resident tissue macrophages, and dendritic cells (DCs) present …

Monocytes are a highly plastic innate immune cell population that displays significant
heterogeneity within the circulation. Distinct patterns of surface marker expression have …

Eosinophils are a type of granulated innate immune cells that have long been implicated in
a specific type of asthma, referred to as eosinophilic asthma. Several immunotherapeutics …

Introduction Peripheral monocytes in humans are conventionally divided into classical (CL,
CD14++ CD16−), intermediate (INT, CD14++ CD16+) and non-classical (NC, CD14dim …

Monocytes are immune regulators implicated in the pathogenesis of type 1 diabetes (T1D),
an autoimmune disease that targets insulin-producing pancreatic β cells. We determined …

Plasmacytoid dendritic cells (pDCs) are a specific dendritic cell type stemming from the
myeloid lineage. Clinically and pathologically, neoplasms associated with pDCs are …

Macrophages are key immune cells in the activation and regulation of immune responses.
These cells are present in all tissues under homeostatic conditions and in many disease …

Starting at birth, newborn infants are exposed to numerous microorganisms. Adaptation of
the innate immune system to them is a delicate process, with potentially advantageous and …