Background Gastroesophageal cancer is a major cause of cancer-related mortality
worldwide. Treatment of both early stage and advanced disease remains highly reliant on …

Simple Summary Microsatellite instability (MSI) is an established predictive biomarker for
immune checkpoint inhibitors with potential prognostic value in different types of tumors. Its …

Background We examined the impact of mismatch repair (MMR) status on efficacy of first-
line fluoropyrimidine plus platinum (FP) chemotherapy in patients with HER2-negative …

Context.—Quality measures that are supported by evidence-based clinical practice
guidelines are preferred for assessing the quality of pathologists' practices. Careful testing of …

Background We aimed to investigate clinicopathologic factors leading to different clinical
outcomes in patients with deficient mismatch repair protein (d-MMR) gastric cancer (GC) …

Background: Although genetic testing has improved our ability to diagnose Lynch syndrome
(LS), there is still limited information on the extent of variations in the clinical and genetic …

Solid-type poorly differentiated adenocarcinoma (solid-type-PDA) of the stomach is a unique
histological subtype of “tubular adenocarcinoma”, but little is known about its …

Background Although universal germline genetic testing is recommended for patients with
exocrine pancreatic cancer (PC), access to genetic testing remains limited in low-and middle …

Methods We performed an extensive review of articles in the PubMed database pertaining to
targeted therapies and immunotherapies in the treatment of metastatic gastric cancer …

Background Lynch syndrome (LS) is a hereditary cancer syndrome caused by pathogenic
germline variants in mismatch repair (MMR) genes, which predisposes to various types of …