In the past decade, novel lamellar keratoplasty techniques such as Deep Anterior Lamellar
Keratoplasty (DALK) for anterior keratoplasty and Descemet stripping automated endothelial …

Corneal neovascularization is a serious condition that can lead to a profound decline in
vision. The abnormal vessels block light, cause corneal scarring, compromise visual acuity …

The cornea is the most commonly transplanted tissue in medicine. The main cause of
corneal graft failure is allograft rejection. The incidence of graft rejection depends on the …

Regulatory T cells (Tregs) are crucial mediators of immune homeostasis. They regulate
immune response by suppressing inflammation and promoting self-tolerance. In addition to …

Avastin® has been clinically proved to be effective in the treatment of intraocular
neovascularization diseases. However, the short half-life of Avastin® need frequent …

Purpose.: To investigate the ability of bevacizumab to penetrate the cornea after topical
application or subconjunctival injection. Methods.: Bevacizumab 1% was topically applied …

Corneal transplantation has been proven effective for returning the gift of sight to those
affected by corneal disorders such as opacity, injury, and infections that are a leading cause …

Corneal lymphangiogenesis is one component of the neovascularization observed in
several inflammatory pathologies of the cornea including dry eye disease and corneal graft …

Purpose.: This study tested the hypothesis that highly targeted intrastromal delivery of
bevacizumab using coated microneedles allows dramatic dose sparing compared with …

Background Graft failure because of immune rejection remains a significant problem in
organ transplantation, and lymphatic and blood vessels are important components of the …