Regulatory enzymes often have different roles in distinct subcellular compartments. Yet,
most drugs indiscriminately saturate the cell. Thus, subcellular drug-delivery holds promise …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Cells respond to environmental cues by mobilizing signal transduction cascades that
engage protein kinases and phosphoprotein phosphatases. Correct organization of these …

Recent advances in neuroscience have positioned brain circuits as key units in controlling
behavior, implying that their positive or negative modulation necessarily leads to specific …

Primary cilia are microtubule-based, non-motile sensory organelles present in most types of
growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit …

In recent years, proximity-dependent biotinylation approaches, including BioID, APEX, and
their derivatives, have been widely used to define the compositions of organelles and other …

Most cancer cells show chromosomal instability, a condition where chromosome
missegregation occurs frequently. We found that chromosome oscillation, an iterative …

To overcome the limitations of traditional pharmacology, the field of photopharmacology has
developed around the central concept of using light to endow drug action with …

Cell division requires the regulation of karyokinesis and cytokinesis, which includes an
essential role of the achromatic spindle. Although the functions of centrosomes are well …

The primary cilium is a microtubule‐based sensory organelle that dynamically links
signalling pathways to cell differentiation, growth, and development. Genetic defects of …