The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …

Poxviruses comprise a large family of viruses characterized by a large, linear dsDNA
genome, a cytoplasmic site of replication and a complex virion morphology. The most …

DNA transport through the cell membrane is an essential requirement for gene therapy,
which utilizes oligonucleotides and plasmid DNA. However, membrane transport of DNA is …

Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are
intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are …

An apple spermidine synthase (SPDS) gene (MdSPDS1) was verified to encode a functional
protein by the complementation of the spe3 yeast mutant, which lacks the SPDS gene. To …

The interactions between aminooxy analogues of the biogenic polyamine spermidine and
selected 15‐mer oligodeoxyribonucleotides with alternating purine–pyrimidine base …

Extracellular and intracellular barriers typically prevent non-viral gene vectors from having
an effective transfection efficiency. Formulation of a gene delivery vehicle that can overcome …

Polyamines (PAs) are linear polycations that are involved in many biological functions.
Putrescine, spermidine and spermine are highly represented in the nucleus of eukaryotic …

Polyamines are positively charged organic cations under physiologic ionic and pH
conditions and hence they interact with negatively charged macromolecules such as DNA …

Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent
polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby …