Bioinspired framework catalysts: From enzyme immobilization to biomimetic catalysis
Enzymatic catalysis has fueled considerable interest from chemists due to its high efficiency
and selectivity. However, the structural complexity and vulnerability hamper the application …
and selectivity. However, the structural complexity and vulnerability hamper the application …
Serial femtosecond crystallography
TRM Barends, B Stauch, V Cherezov… - Nature reviews Methods …, 2022 - nature.com
With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …
crystallography techniques for macromolecular structure determination have emerged …
Metabolic and pharmaceutical aspects of fluorinated compounds
BM Johnson, YZ Shu, X Zhuo… - Journal of medicinal …, 2020 - ACS Publications
The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …
understanding of its effects on physicochemical properties and the development of synthetic …
3d transition metals for C–H activation
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …
notable applications to material sciences, crop protection, drug discovery, and …
Oxygen activation and radical transformations in heme proteins and metalloporphyrins
As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …
Enantioselective Transformations in the Synthesis of Therapeutic Agents
H Yang, H Yu, IA Stolarzewicz, W Tang - Chemical Reviews, 2023 - ACS Publications
The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …
Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
Mechanisms of cytochrome P450-catalyzed oxidations
FP Guengerich - ACS catalysis, 2018 - ACS Publications
Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …
Second sphere effects on oxygen reduction and peroxide activation by mononuclear iron porphyrins and related systems
Activation and reduction of O2 and H2O2 by synthetic and biosynthetic iron porphyrin
models have proved to be a versatile platform for evaluating second-sphere effects deemed …
models have proved to be a versatile platform for evaluating second-sphere effects deemed …
[HTML][HTML] Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of …
TY Hargrove, L Friggeri, Z Wawrzak, A Qi… - Journal of Biological …, 2017 - ASBMB
With some advances in modern medicine (such as cancer chemotherapy, broad exposure to
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …
antibiotics, and immunosuppression), the incidence of opportunistic fungal pathogens such …