Spatiotemporal metabolic liver zonation and consequences on pathophysiology
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
Interorgan rhythmicity as a feature of healthful metabolism
J Bass - Cell metabolism, 2024 - cell.com
The finding that animals with circadian gene mutations exhibit diet-induced obesity and
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …
metabolic syndrome with hypoinsulinemia revealed a distinct role for the clock in the brain …
Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …
specific gene expression rhythms and how these depend on age and sex is not defined in …
[HTML][HTML] Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals
Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a
daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health …
daily cycle of feeding and fasting. In both animals and humans, TRF has pleiotropic health …
Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice
J Lee, JM Dimitry, JH Song, M Son… - Nature …, 2023 - nature.com
Alzheimer's disease, the most common age-related neurodegenerative disease, is
characterized by tau aggregation and associated with disrupted circadian rhythms and …
characterized by tau aggregation and associated with disrupted circadian rhythms and …
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease
Obesity and liver diseases are associated with the disruption of the circadian clock that
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …
Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome
Compositional oscillations of the gut microbiome are essential for normal peripheral
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
Intercellular coupling between peripheral circadian oscillators by TGF-β signaling
AM Finger, S Jäschke, M Del Olmo, R Hurwitz… - Science …, 2021 - science.org
Coupling between cell-autonomous circadian oscillators is crucial to prevent
desynchronization of cellular networks and disruption of circadian tissue functions. While …
desynchronization of cellular networks and disruption of circadian tissue functions. While …
Venn diagram analysis overestimates the extent of circadian rhythm reprogramming
The circadian clock modulates key physiological processes in many organisms. This
widespread role of circadian rhythms is typically characterized at the molecular level by …
widespread role of circadian rhythms is typically characterized at the molecular level by …