The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

The supply of oxygen and nutrients to tissues is performed by the blood system and involves
a net leakage of fluid outward at the capillary level. One of the principal functions of the …

The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …

Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives
cancer progression, although the pathways of tumour cell dissemination are unclear. Here …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Lymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early
lymphatic-valve morphogenesis and the role of biomechanical forces are not well …

Interstitial flow plays important roles in the morphogenesis, function, and pathogenesis of
tissues. To investigate these roles and exploit them for tissue engineering or to overcome …

Vascular remodeling under conditions of growth or exercise, or during recovery from arterial
restriction or blockage is essential for health, but mechanisms are poorly understood. It has …