Multicomponent reactions are flexible reactions for the rapid generation of complex
molecules with often biologically relevant scaffold structures. Combined with the ease of …

Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

The recently developed artificial force induced reaction (AFIR) method was applied to
search systematically all possible multicomponent pathways for the Biginelli reaction …

The present work describes the synthesis, characterization, and application of a new ion‐
tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive …

The heterocyclic ring system of pyrido [2, 3-d] pyrimidines is a privileged scaffold in
medicinal chemistry, possessing several biological activities. The synthesis of the pyrimidine …

Alzheimer's disease (AD) is multifactorial, progressive neurodegeneration with impaired
behavioural and cognitive functions. The multitarget-directed ligand (MTDL) strategies are …

The interest in 3, 4-dihydropyrimidine-2 (1 H)-(thio) ones is increasing every day, mainly due
to their paramount biological relevance. The Biginelli reaction is the classical approach to …

Abstract The pyrido [2, 3‐d] pyrimidine moieties are one of the most biologically widespread
heterocyclic compounds as antimicrobial, antioxidant, antitubercular, antiviral and anti …

Thiourea derivatives (6a–e) were developed and screened for antitumor and anti-
inflammatory activity. Most of the compounds exhibited growth inhibitory effects comparable …

Recently, heterocyclic compounds such as pyrido [2, 3-d] pyrimidinones, 1, 2, 4-
triazolopyrimidines, pyrimidoquinazolines, and quinoline derivatives have gained attention …