BACKGROUND Metabolic reprogramming is a hallmark of malignancy first recognized a
century ago. In some cases, reprogrammed metabolic activities can be exploited to …

Metastasis is the main cause of death in people with cancer. To colonize distant organs,
circulating tumour cells must overcome many obstacles through mechanisms that we are …

Most metastasizing tumor cells reach distant sites by entering the circulatory system. Within
the bloodstream, they are exposed to severe stress due to loss of adhesion to extracellular …

Cancer metastasis is the leading cause of mortality in patients with cancer. Theories have
been developed to explain the causes and principles of metastasis. Metastasis is attributed …

Metastasis is powered by disseminated cancer cells that re-create a full-fledged tumor in
unwelcoming tissues, away from the primary site. How cancer cells moving from a tumor into …

Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in
distant organs. Here we find that lung mesenchymal stromal cells (LMSCs) at pre-metastatic …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Metastases, rather than primary tumours, are responsible for most cancer deaths. To prevent
these deaths, improved ways to treat metastatic disease are needed. Blood flow and other …

Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is
associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has …

Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …