The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …

Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the
sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin …

Animals possess a wide variety of muscle types that support different kinds of movements.
Different muscles have distinct locations, morphologies and contractile properties, raising …

Measuring the positions and dynamics of proteins in intact tissues or whole animals is key to
understanding protein function. However, to date, this is challenging, as the accessibility of …

Simple Summary There are three subfamilies of human PDZ-LIM family proteins with a total
of 10 protein molecules, and PDZ-LIM family proteins serve as a class of scaffolding proteins …

The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this
study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for …

Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-
producing myofibrils. During development, the size of individual muscle fibers must …

Myofibrils are the intracellular structures formed by actin and myosin filaments. They are
paracrystalline contractile cables with unusually well-defined dimensions. The sliding of …

During striated muscle development the first periodically repeated units appear in the
premyofibrils, consisting of immature sarcomeres that must undergo a substantial growth …

In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight
and leg muscles are the major voluntary locomotory organs. They share several …