The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner
and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β …

Therapeutic interventions aimed at inducing fetal hemoglobin and reducing the
concentration of sickle hemoglobin is an effective approach to ameliorating acute and …

Beta-thalassemia is a well-known blood genetic disorder inherited in an autosomal
recessive manner. Beta-thalassemia is found everywhere in the world as a rare, relatively …

Background As new treatment options for patients with higher-risk myelodysplastic
syndromes are emerging, identification of prognostic markers for hypomethylating agent …

β-Thalassemia is an inherited genetic disorder associated with β-globin chain synthesis,
which ultimately becomes anemia. Adenosine-2, 3-dialdehyde, by inhibiting arginine methyl …

Lead (Pb) is a prevalent environmental toxic metal that may harmfully affect the function of
the thyroid gland. Our information about the effects of lead on thyroid function in lead …

Quasi-palindromic sequences (AT) X N12 (AT) Y present in HS2 (hypersensitive site 2) of
the human β-globin locus are known to be significantly associated with increased fetal …

Hemoglobin (Hb) disorders are the most common inherited blood disorders in the world. β-
hemoglobinopathies, such as sickle cell disease (SCD) and β-thalassemia result from …