The transforming growth factor (TGF) beta superfamily of secreted factors is comprised of
over 30 members including Activins, Nodals, Bone Morphogenetic Proteins (BMPs), and …

The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Cofilin and actin-depolymerizing factor (ADF) are actin-binding proteins that play an
essential role in regulating actin filament dynamics and reorganization by stimulating the …

Motile growth cones lead growing axons through developing tissues to synaptic targets.
These behaviors depend on the organization and dynamics of actin filaments that fill the …

Hereditary spastic paraplegias (HSP) are a heterogeneous group of motor
neurodegenerative disorders that have the core clinical presentation of pyramidal syndrome …

Voluntary movement is a fundamental way in which animals respond to, and interact with,
their environment. In mammals, the main CNS pathway controlling voluntary movement is …