Protein analysis by shotgun/bottom-up proteomics

Y Zhang, BR Fonslow, B Shan, MC Baek… - Chemical …, 2013 - ACS Publications
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

[HTML][HTML] Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs

P Zhang, S Woen, T Wang, B Liau, S Zhao, C Chen… - Drug discovery today, 2016 - Elsevier
Highlights•Glycosylation of antibodies has a range of effects on their binding and effector
functions.•Regulatory agencies require stringent glycan analysis to ensure safety and …

GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans

A Ceroni, K Maass, H Geyer, R Geyer… - Journal of proteome …, 2008 - ACS Publications
Mass spectrometry is the main analytical technique currently used to address the challenges
of glycomics as it offers unrivalled levels of sensitivity and the ability to handle complex …

Glycomics: an integrated systems approach to structure-function relationships of glycans

R Raman, S Raguram, G Venkataraman, JC Paulson… - Nature …, 2005 - nature.com
In comparison with genomics and proteomics, the advancement of glycomics has faced
unique challenges in the pursuit of developing analytical and biochemical tools and …

MS‐based glycomics and glycoproteomics methods enabling isomeric characterization

W Peng, CD Gutierrez Reyes, S Gautam… - Mass spectrometry …, 2023 - Wiley Online Library
Glycosylation is one of the most significant and abundant posttranslational modifications in
mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell …

Strategies for analysis of glycoprotein glycosylation

H Geyer, R Geyer - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2006 - Elsevier
Glycoproteins are known to exhibit multiple biological functions. In order to assign distinct
functional properties to defined structural features, detailed information on the respective …

Saliva proteome research: current status and future outlook

BL Schulz, J Cooper-White… - Critical reviews in …, 2013 - Taylor & Francis
Human saliva harbours proteins of clinical relevance and about 30% of blood proteins are
also present in saliva. This highlights that saliva can be used for clinical applications just as …

Structural Feature Ions for Distinguishing N- and O-Linked Glycan Isomers by LC-ESI-IT MS/MS

AV Everest-Dass, JL Abrahams… - Journal of the …, 2013 - ACS Publications
Glycomics is the comprehensive study of glycan expression in an organism, cell, or tissue
that relies on effective analytical technologies to understand glycan structure–function …

Plant cell wall proteomics: the leadership of Arabidopsis thaliana

C Albenne, H Canut, E Jamet - Frontiers in plant science, 2013 - frontiersin.org
Plant cell wall proteins (CWPs) progressively emerged as crucial components of cell walls
although present in minor amounts. Cell wall polysaccharides such as pectins …

A strategy for discovery of cancer glyco‐biomarkers in serum using newly developed technologies for glycoproteomics

H Narimatsu, H Sawaki, A Kuno, H Kaji, H Ito… - The FEBS …, 2010 - Wiley Online Library
Detection of cancer at early stages that can be treated through surgery is a difficult task. One
methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by …