Bacteria in cancer initiation, promotion and progression

G El Tekle, WS Garrett - Nature Reviews Cancer, 2023 - nature.com
Cancer cells originate from a series of acquired genetic mutations that can drive their
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …

Congenital adrenal hyperplasia—current insights in pathophysiology, diagnostics, and management

HL Claahsen-van der Grinten, PW Speiser… - Endocrine …, 2022 - academic.oup.com
Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling

BY Shorning, MS Dass, MJ Smalley… - International journal of …, 2020 - mdpi.com
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective

S Kumariya, V Ubba, RK Jha, JR Gayen - Autophagy, 2021 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is a unification of endocrine and metabolic disorders and
has become immensely prevalent among women of fertile age. The prime organ affected in …

Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women

SH Ko, HS Kim - Nutrients, 2020 - mdpi.com
Menopause is clinically diagnosed as a condition when a woman has not menstruated for
one year. During the menopausal transition period, there is an emergence of various lipid …

Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides

AT Slominski, RM Slominski… - … of Physiology-Cell …, 2022 - journals.physiology.org
The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …

Circulating testosterone as the hormonal basis of sex differences in athletic performance

DJ Handelsman, AL Hirschberg, S Bermon - Endocrine reviews, 2018 - academic.oup.com
Elite athletic competitions have separate male and female events due to men's physical
advantages in strength, speed, and endurance so that a protected female category with …

Immune regulation by glucocorticoids

DW Cain, JA Cidlowski - Nature Reviews Immunology, 2017 - nature.com
Endogenous glucocorticoids are crucial to various physiological processes, including
metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have …

Exploring vitamin D metabolism and function in cancer

SM Jeon, EA Shin - Experimental & molecular medicine, 2018 - nature.com
Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid
hormone that regulates a broad spectrum of physiological processes. In addition to its …

Leydig cells: formation, function, and regulation

BR Zirkin, V Papadopoulos - Biology of reproduction, 2018 - academic.oup.com
Herein we summarize important discoveries made over many years about Leydig cell
function and regulation. Fetal Leydig cells produce the high levels of androgen (testosterone …