COVID-19 outbreak, caused by severe acute respiratory syndrome (SARS)-CoV-2
coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor …

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes
mellitus and the leading cause of end-stage kidney disease. The standard treatments for …

COVID-19, the disease caused by the novel Coronavirus, SARS-CoV-2, is increasingly
being recognized as a systemic thrombotic and microvascular injury syndrome that may …

Acute respiratory failure and a systemic coagulopathy are critical aspects of the morbidity
and mortality characterizing infection with severe acute respiratory distress syndrome …

The objective of this study was to elucidate the pathophysiology that underlies severe
COVID-19 by assessing the histopathology and the in situ detection of infectious SARS-CoV …

COVID-19 and the renin-angiotensin system (RAS) are linked by angiotensin-converting
enzyme 2 (ACE2), a key enzyme in RAS that has been validated as a SARS-CoV-2 receptor …

Diffuse pulmonary inflammation, endothelial inflammation, and enhanced thrombosis are
cardinal features of coronavirus disease 2019 (COVID-19), the disease caused by the …

The global pandemic COVID‐19 has resulted in significant global morbidity, mortality and
increased healthcare demands. There is now emerging evidence of patients experiencing …

Angiotensin-converting enzyme 2 (ACE2), first discovered in 2000, serves as an important
counterregulatory enzyme to the angiotensin II-mediated vasoconstrictive, pro-inflammatory …

MasR is a critical element in the RAS accessory pathway that protects the heart against
myocardial infarction, ischemia-reperfusion injury, and pathological remodeling by …