Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Alzheimer's disease (AD) is a major cause of dementia in the elderly. Pathologically, AD is
characterized by the accumulation of insoluble aggregates of Aβ-peptides that are …

Increasing evidence suggests that the accumulation of amyloid beta (Aβ) in synapses and
synaptic mitochondria causes synaptic mitochondrial failure and synaptic degeneration in …

The ability to change behavior likely depends on the selective strengthening and weakening
of brain synapses. The cellular models of synaptic plasticity, long-term potentiation (LTP) …

Aerobes require oxygen for metabolism and normal free radical formation. As a result,
maintaining the redox homeostasis is essential for brain cell survival due to their high …

Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …

Although amyloid β (Aβ) oligomers are presumed to cause synaptic and cognitive
dysfunction in Alzheimer's disease (AD), their contribution to other pathological features of …

Aggregation of amyloid-β (Aβ) peptide into soluble and insoluble forms within the brain
extracellular space is central to the pathogenesis of Alzheimer's disease. Full-length amyloid …

Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease.
Amyloid beta (Aβ), a peptide secreted in an activity-modulated manner by neurons, has …

Alzheimer's disease (AD) is the most common cause of dementia among older people.
There are no effective medications currently available to prevent and treat AD and halt …