Janus protein tyrosine kinase (JAK) has the ability to activate signal transducer and activator
of transcription (STAT). STAT3 is a valued member of the JAK/STAT signaling pathway. In …

Fibrotic remodelling is a highly conserved protective response to tissue injury and it is
essential for the maintenance of structural and functional tissue integrity. Also hepatic …

Background: The articular cartilage is unique in that it contains only a single type of cell and
shows poor ability for spontaneous healing. Currently, approaches for treating cartilage …

Therapeutic potential of bone marrow–derived mesenchymal stem cells (BM-MSCs) has
been reported in several animal models of liver fibrosis. Interleukin (IL) 17A, IL6 and Stat3 …

The whole liver transplantation is the most effective treatment for end-stage fibrosis.
However, the lack of available donors, immune rejection and total cost of surgery remain as …

Regenerative medicine has an exciting prospective to bring preventive and therapeutic
benefits to a myriad of diseases. Different biological factors such as growth factors …

Background: In end-stage chronic liver disease, transplantation represents the only curative
option. However, the shortage of donors results in the death of many patients. To overcome …

This review describes the freeze‐dried mesenchymal stem cells (MSCs) and their ability to
restore damaged tissues and organs. An analysis of the literature shows that after the …

Objective The aim of the study was to evaluate the efficacy and safety of umbilical cord blood
stem cells (USCs) transplantation combined with routine supportive therapy (RST) for liver …

To investigate the anti-oxidant activities and mechanism of rosmarinic acid (RA) on rat bone
marrow mesenchymal stem cells (rBMSCs) from ischemia-induced apoptosis in vitro, which …