In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …

The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide
an unprecedented cell source for drug discovery and cell transplantation therapy in …

Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …

In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …

In a significant fraction of breast cancer patients, distant metastases emerge after years or
even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and …

Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators
of vascular morphogenesis and function during development, cardiovascular homeostasis …

Transplantation of in-vitro-generated organ buds is a promising approach toward
regenerating functional and vascularized organs. Though it has been recently shown in the …