Histone deacetylases (HDACs) are enzymes that play a role in chromatin remodeling and
epigenetics. They belong to a specific category of enzymes that eliminate the acetyl part of …

A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using
microwave-assisted three-component reactions is reported in this study. Novel …

A novel series of indolyl oxoacetamide-quinazolinone hybrid analogues (9aa–9df) were
designed, synthesized, and evaluated for their in vitro pancreatic lipase (PL) inhibitory …

Plant bacterial illnesses are common and cause dramatic damage to agricultural goods all
over the world, yet there are few efficient bactericides to alleviate them at present. To …

The cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of
interferon genes–TANK-binding kinase 1–interferon regulating factor 3 (cGAS-STING-TBK1 …

An efficient radical cascade cyclization of unactivated alkenes toward the synthesis of a
series of ring-fused quinazolinones has been developed in moderate to excellent yields …

A mild, external photocatalyst‐and additive‐free protocol for photo‐induced
alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy …

The heterocyclic compounds have a great significance in medicinal chemistry because they
have extensive biological activities. Cancer is globally the leading cause of death and it is a …

Nur77 is a potential target for the treatment of cancer such as HCC. Herein, we detailed the
discovery of a novel series of 5-((8-methoxy-2-methylquinolin-4-yl) amino)-1H-indole-2 …

In continuation of our previous work on the investigation of CDK9 inhibitors bearing indole
moiety for the discovery of novel anticancer agents, novel methylenehydrazine-1 …