Targeting the M1 muscarinic acetylcholine receptor in Alzheimer's disease
Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …
despite extensive research, only a few drugs are available for management of the disease …
Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease
M Scarpa, C Molloy, L Jenkins… - Proceedings of the …, 2021 - National Acad Sciences
There are currently no treatments that can slow the progression of neurodegenerative
diseases, such as Alzheimer's disease (AD). There is, however, a growing body of evidence …
diseases, such as Alzheimer's disease (AD). There is, however, a growing body of evidence …
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome
We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …
Investigating protein expression, modifications and interactions in the brain: Protocol for preparing rodent brain tissue for mass spectrometry-based quantitative-and …
L Dwomoh - Methods in Cell Biology, 2021 - Elsevier
Neurodegenerative diseases remain a major global health challenge, affecting millions of
individuals worldwide. Despite significant research efforts, the etiology and pathological …
individuals worldwide. Despite significant research efforts, the etiology and pathological …