[HTML][HTML] Understanding the role of neutrophils in chronic inflammatory airway disease
Airway neutrophilia is a common feature of many chronic inflammatory lung diseases and is
associated with disease progression, often regardless of the initiating cause. Neutrophils …
associated with disease progression, often regardless of the initiating cause. Neutrophils …
Acute respiratory distress syndrome and COVID-19: A literature review
M Hussain, S Khurram Syed, M Fatima… - Journal of …, 2021 - Taylor & Francis
Acute respiratory distress syndrome (ARDS) is an overwhelming inflammatory disorder of
the lung due to direct and indirect insults to the lungs. ARDS is characterized by increased …
the lung due to direct and indirect insults to the lungs. ARDS is characterized by increased …
In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …
Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19
A Gupta, MV Madhavan, TJ Poterucha… - Nature …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state,
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …
leading to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …
Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study
P Sinha, KL Delucchi, BT Thompson, DF McAuley… - Intensive care …, 2018 - Springer
Purpose Using latent class analysis (LCA), we have consistently identified two distinct
subphenotypes in four randomized controlled trial cohorts of ARDS. One subphenotype has …
subphenotypes in four randomized controlled trial cohorts of ARDS. One subphenotype has …
Simvastatin improves neutrophil function and clinical outcomes in pneumonia. A pilot randomized controlled clinical trial
Rationale: Population studies suggest improved sepsis outcomes with statins, but the results
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …
Precision medicine and heterogeneity of treatment effect in therapies for ARDS
YA Khan, E Fan, ND Ferguson - Chest, 2021 - Elsevier
ARDS is a clinically heterogeneous syndrome, rather than a distinct disease. This
heterogeneity at least partially explains the difficulty in studying treatments for these patients …
heterogeneity at least partially explains the difficulty in studying treatments for these patients …
Pulmonary infections in the elderly lead to impaired neutrophil targeting, which is improved by simvastatin
Rationale: Dysregulated neutrophil functions with age and sepsis are described. Statins are
associated with improved infection survival in some observational studies, but trials in …
associated with improved infection survival in some observational studies, but trials in …
Association between cardiometabolic risk factors and COVID-19 susceptibility, severity and mortality: a review
The novel coronavirus, which began spreading from China Wuhan and gradually spreaded
to most countries, led to the announcement by the World Health Organization on March 11 …
to most countries, led to the announcement by the World Health Organization on March 11 …
Statins suppress Ebola virus infectivity by interfering with glycoprotein processing
Ebola virus (EBOV) infection is a major public health concern due to high fatality rates and
limited effective treatments. Statins, widely used cholesterol-lowering drugs, have pleiotropic …
limited effective treatments. Statins, widely used cholesterol-lowering drugs, have pleiotropic …