Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

The prescription of pharmaceuticals in the critically ill is complicated by a paucity of
knowledge concerning the pharmacokinetic implications of the underlying disease state …

These guidelines were formulated to assist physicians and other health care professionals
with various aspects of the administration of outpatient parenteral antimicrobial therapy …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients. Selecting the appropriate antimicrobial at the …

Background and Objective The necessity of therapeutic drug monitoring (TDM) for
vancomycin is controversial. The objective of the current review was to evaluate the …

Despite the development of novel antibiotics active against Gram-positive bacteria,
vancomycin generally remains the first treatment, although rapidly achieving concentrations …

Abstract Treatment of sepsis remains a significant challenge with persisting high mortality
and morbidity. Early and appropriate antibacterial therapy remains an important intervention …

Augmented renal clearance (ARC) has been reported in approximately 30–65% of patients
in the intensive care unit (ICU) despite the presence of a normal serum creatinine …

Objectives The aims of this study were to develop a population pharmacokinetic model of
vancomycin in adult patients, to use this model to develop dosage guidelines targeting …