Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Kidney damage varies according to the primary insult. Different aetiologies of acute kidney
injury (AKI), including kidney ischaemia, exposure to nephrotoxins, dehydration or sepsis …

Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …

Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …