Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …

Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniasis and
Chagas disease, respectively, two neglected tropical diseases that affect about 25 million …

Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …

The outcome of an infection with any given pathogen varies according to the dosage and
route of infection, but, in addition, the physiological state of the host can determine the …

The COVID pandemic has refreshed and expanded recognition of the vital role that
sustained antibody (Ab) secretion plays in our immune defenses against microbes and of …

Introduction Cellular circuits sense the environment, process signals, and compute
decisions using networks of interacting proteins. Emerging high-dimensional single-cell …

A proper balance between Th17 and T regulatory cells (Treg cells) is critical for generating
protective immune responses while minimizing autoimmunity. We show that the Tec family …

IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …

Bile acids are established signaling molecules next to their role in the intestinal
emulsification and uptake of lipids. We here aimed to identify a potential interaction between …

T follicular helper (Tfh) cells play essential roles in regulating humoral immunity, especially
germinal center reactions. However, how CD4+ T cells integrate the antigenic and …