Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated
with global morbidity and early mortality. More effective and inexpensive therapies are …

This review focuses on the contribution of abnormal blood rheology in the pathophysiology
of sickle cell anemia (SCA). SCA is characterized by a reduction of red blood cell (RBC) …

The contribution of intracellular hemoglobin (Hb) oxidation to RBC-derived microparticle
(MP) formation is poorly defined in sickle cell disease (SCD). Here we report that sickle Hb …

Background: Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential
inflammatory marker in sickle cell disease (SCD). This study aimed to evaluate the impact of …

Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single point
mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin polymerizes …

Sickle cell anaemia (SCA) is a chronic inflammatory disease with a complex mechanism of
pathogenesis. The rheological phenomenon of SCA has been directly associated with the …

People with sickle cell disease (SCD) are at greater risk of severe illness and death from
respiratory infections, including COVID-19, than people without SCD (Centers for Disease …

This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and
inflammatory parameters in children with sickle cell anemia (SCA) in association with βS …

Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common
inherited disease in the world. Although complications of sickle cell disease start from …

The ubiquitin‐proteasome system (UPS) is an important intracellular proteolytic pathway
responsible for the degradation of proteins and oxidative damage; hence it plays a central …