Parkinson's disease: biomarkers, treatment, and risk factors

FN Emamzadeh, A Surguchov - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused mainly by
lack of dopamine in the brain. Dopamine is a neurotransmitter involved in movement …

EFNS/MDS‐ES recommendations for the diagnosis of P arkinson's disease

A Berardelli, GK Wenning, A Antonini… - European journal of …, 2013 - Wiley Online Library
Background A Task Force was convened by the EFNS/MDS‐ES Scientist Panel on P
arkinson's disease (PD) and other movement disorders to systemically review relevant …

EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

S Morbelli, G Esposito, J Arbizu, H Barthel… - European journal of …, 2020 - Springer
Purpose This joint practice guideline or procedure standard was developed collaboratively
by the European Association of Nuclear Medicine (EANM) and the Society of Nuclear …

[HTML][HTML] Reduced dopamine receptors and transporters but not synthesis capacity in normal aging adults: a meta-analysis

TM Karrer, AK Josef, R Mata, ED Morris… - Neurobiology of …, 2017 - Elsevier
Many theories of cognitive aging are based on evidence that dopamine (DA) declines with
age. Here, we performed a systematic meta-analysis of cross-sectional positron emission …

Biomarkers in Parkinson's disease

A Surguchov - … diseases biomarkers: Towards translating research to …, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a
documented significant increase in its prevalence in the past three decades. Both …

Recent advances in biomarkers for Parkinson's disease

R He, X Yan, J Guo, Q Xu, B Tang… - Frontiers in aging …, 2018 - frontiersin.org
Parkinson's disease (PD) is one of the common progressive neurodegenerative disorders
with several motor and non-motor symptoms. Most of the motor symptoms may appear at a …

Gait speed in Parkinson disease correlates with cholinergic degeneration

NI Bohnen, KA Frey, S Studenski, V Kotagal… - Neurology, 2013 - AAN Enterprises
Objective: We investigated dopaminergic and cholinergic correlates of gait speed in
Parkinson disease (PD) and non-PD control subjects to test the hypothesis that gait …

Influences of dopaminergic system dysfunction on late-life depression

WD Taylor, DH Zald, JC Felger, S Christman… - Molecular …, 2022 - nature.com
Deficits in cognition, reward processing, and motor function are clinical features relevant to
both aging and depression. Individuals with late-life depression often show impairment …

Novel focused ultrasound gene therapy approach noninvasively restores dopaminergic neuron function in a rat Parkinson's disease model

BP Mead, N Kim, GW Miller, D Hodges… - Nano …, 2017 - ACS Publications
Therapies capable of decelerating, or perhaps even halting, neurodegeneration in
Parkinson's disease (PD) remain elusive. Clinical trials of PD gene therapy testing the …

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

DS Goldstein, P Sullivan, C Holmes… - Journal of …, 2013 - Wiley Online Library
Intra‐neuronal metabolism of dopamine (DA) begins with production of 3, 4‐
dihydroxyphenylacetaldehyde (DOPAL), which is toxic. According to the 'catecholaldehyde …