Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Cerebrovascular endothelial cells (CECs) are integral components of both the blood‐brain
barrier (BBB) and the neurovascular unit (NVU). As the primary cell type of the BBB, CECs …

Vascular cognitive impairment and dementia (VCID) is the second most common form of
dementia after Alzheimer's disease (AD). Currently, the mechanistic insights into the …

Vascular dementia (VaD) is the second most common form of dementia worldwide. It is
caused by cerebrovascular disease, and patients often show severe impairments of …

Cognitive impairment (CI) is a major health concern in aging populations. It impairs patients'
independent life and may progress to dementia. Vascular cognitive impairment (VCI) …

The loss of cerebral autoregulation (CA) is a common and detrimental secondary injury
mechanism following acute brain injury and has been associated with worse morbidity and …

Tauopathies refer to a group of neurodegenerative diseases with intracellular accumulation
of hyperphosphorylated and aggregated microtubule-associated protein tau (MAPT) in …

Research in preclinical models indicates that estrogens are neuroprotective and positively
impact cognitive aging. However, clinical data are equivocal as to the benefits of …

Alzheimer's disease (AD) is the leading cause of mortality, disability, and long‐term care
burden in the United States, with women comprising the majority of AD diagnoses. While AD …

Increasing evidence implicates endothelial dysfunction in the pathogenesis of Alzheimer's
disease (AD). Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is essential in …