Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …
and progression and have potential to produce clinically useful biomarkers. A growing body …
The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential …
Biobanks linked to electronic health records provide rich resources for health‐related
research. With improvements in administrative and informatics infrastructure, the availability …
research. With improvements in administrative and informatics infrastructure, the availability …
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
S Sanchez-Roige, MV Jennings, HHA Thorpe… - Translational …, 2023 - nature.com
Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to
act prematurely and is associated with multiple forms of psychopathology, including …
act prematurely and is associated with multiple forms of psychopathology, including …
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …
about the mechanisms that influence these traits. Combining data for up to 703,901 …
To donate or not to donate? Future healthcare professionals' opinions on biobanking of human biological material for research purposes
Background Over the last few decades biobanks have been recognised as institutions that
may revolutionise biomedical research and the development of personalised medicine …
may revolutionise biomedical research and the development of personalised medicine …
[HTML][HTML] Better the devil you know than the devil you don't: Neural processing of risk and ambiguity
Risk and ambiguity are inherent in virtually all human decision-making. Risk refers to a
situation in which we know the precise probability of potential outcomes of each option …
situation in which we know the precise probability of potential outcomes of each option …
Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores
Bipolar disorder (BD) has high clinical heterogeneity, frequent psychiatric comorbidities, and
elevated suicide risk. To determine genetic differences between common clinical sub …
elevated suicide risk. To determine genetic differences between common clinical sub …
[HTML][HTML] Risk-taking in humans and the medial orbitofrontal cortex reward system
Risk-taking differs between humans, and is associated with the personality measures of
impulsivity and sensation-seeking. To analyse the brain systems involved, self-report risk …
impulsivity and sensation-seeking. To analyse the brain systems involved, self-report risk …
The longitudinal relationship between screen time, sleep and a diagnosis of attention-deficit/hyperactivity disorder in childhood
B Levelink, M van der Vlegel… - Journal of attention …, 2021 - journals.sagepub.com
Objective: To evaluate longitudinal associations between recreational screen time and sleep
in early childhood, and attention-deficit/hyperactivity disorder (ADHD) at age 8 to 10 years …
in early childhood, and attention-deficit/hyperactivity disorder (ADHD) at age 8 to 10 years …