Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Ion channels in the plasma membrane of vascular muscle cells that form the walls of
resistance arteries and arterioles play a central role in the regulation of vascular tone …

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The dense network of capillaries composed of capillary endothelial cells (cECs) and
pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron-and …

Local intracellular Ca2+ transients, termed Ca2+ sparks, are caused by the coordinated
opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic …

Among the TRPC subfamily of TRP (classical transient receptor potential) channels, TRPC3,-
6, and-7 are gated by signal transduction pathways that activate C-type phospholipases as …

cGMP is a second messenger that produces its effects by interacting with intracellular
receptor proteins. In smooth muscle cells, one of the major receptors for cGMP is the …

Local calcium transients ('Ca2+ sparks') are thought to be elementary Ca2+ signals in heart,
skeletal and smooth muscle cells. Ca2+ sparks result from the opening of a single, or the …

The concentration of cytoplasmic Ca2+ regulates the contractile state of smooth muscle cells
and tissues. Elevations in global cytoplasmic Ca2+ resulting in contraction are …

Hypertension is a clinical syndrome characterized by increased vascular tone. However, the
molecular mechanisms underlying vascular dysfunction during acquired hypertension …