Diabetes mellitus (DM) is a critical global health issue, affecting nearly half a billion people
worldwide, with an increasing incidence rate and mortality. Type 2 diabetes is caused by the …

In the field of heterocyclic synthesis, alkynyl aldehydes serve as privileged reagents for
cyclization reactions with other organic compounds to construct a broad spectrum of N-, O …

New series of thioquinoline structures bearing phenylacetamide 9a–p were designed,
synthesized and the structure of all derivatives was confirmed using different spectroscopic …

In this work, a new series of quinoline–quinazolinone–thioacetamide derivatives 9a–p were
designed using a combination of effective pharmacophores of the potent α-glucosidase …

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by high blood
sugar levels. It was shown that modulating the activity of α-glucosidase, an enzyme involved …

Diabetes mellitus is a severe metabolic disorder, which has very high prevalence rate and
resulting into other health devastating complications. Pancreatic insulin resistance and-cell …

The development of new antidiabetes agents is necessary to obtain optimal glycemic control
and overcome its complications. Different quinazolin-4 (3 H)-one bearing phenoxy …

In the present study, new structural variants of 4-hydroxyquinolinone-hydrazones were
designed and synthesized. The structure elucidation of the synthetic derivatives 6a–o was …

Background: The aminoquinoline core exhibits versatile pharmacological properties,
particularly in the area of anticancer activity. This study was designed to investigate the …

Design, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl)
Acetamide as Antidiabetic Agent - PMC Back to Top Skip to main content NIH NLM Logo …