Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem
SF Sousa, PA Fernandes… - Current medicinal …, 2008 - ingentaconnect.com
Farnesyltransferase (FTase) is a zinc enzyme that has been the subject of particular
attention in anti-cancer research. This enzyme promotes the addition of a farnesyl group …
attention in anti-cancer research. This enzyme promotes the addition of a farnesyl group …
The first total synthesis of dragmacidin D
NK Garg, R Sarpong, BM Stoltz - Journal of the American …, 2002 - ACS Publications
The first total synthesis of the biologically significant bis-indole alkaloid dragmacidin D (5)
has been achieved. Thermal and electronic modulation provides the key for a series of …
has been achieved. Thermal and electronic modulation provides the key for a series of …
Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa
The biofilm formation of Pseudomonas aeruginosa, an opportunistic human pathogen, is
developed by cell-to-cell signaling, so-called quorum sensing (QS). To control the biofilm …
developed by cell-to-cell signaling, so-called quorum sensing (QS). To control the biofilm …
Weakly Coordinating, Ketone‐Directed (η5‐Pentamethylcyclopentadienyl)cobalt(III)‐ and (η5‐Pentamethylcyclopentadienyl)rhodium(III)‐Catalyzed C−H Amidation …
The weakly coordinating, ketone‐directed, regioselective monoamidation of aromatic
ketones, chalcone, carbazole, and benzophenones was achieved by employing high‐valent …
ketones, chalcone, carbazole, and benzophenones was achieved by employing high‐valent …
Acid-free regioselective aminocarbonylation of alkenes
Acid-free regioselective aminocarbonylation of alkenes - Chemical Communications (RSC
Publishing) DOI:10.1039/C4CC02167C Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/C4CC02167C Royal Society of Chemistry View PDF VersionPrevious …
A unified synthetic approach to the pyrazinone dragmacidins
A unified synthetic approach to the pyrazinone dragmacidins - Chemical Communications (RSC
Publishing) DOI:10.1039/B605929E Royal Society of Chemistry View PDF VersionPrevious …
Publishing) DOI:10.1039/B605929E Royal Society of Chemistry View PDF VersionPrevious …
Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides
PG Li, H Zhu, M Fan, C Yan, K Shi, XW Chi… - Organic & Biomolecular …, 2019 - pubs.rsc.org
Copper-catalyzed coupling of α-keto acids with anthranils is reported for the synthesis of α-
ketoamides. This process involves N–O/C–O bond cleavages and C–N bond formation …
ketoamides. This process involves N–O/C–O bond cleavages and C–N bond formation …
Ru (II)-Catalyzed Weakly Coordinating Carbonyl-Assisted Dialkynylation of (Hetero) Aryl Ketones
Functionalized aryl (heteroaryl) ketones are present in many natural products as key
structural components and serve as basic synthetic building blocks for various organic …
structural components and serve as basic synthetic building blocks for various organic …
Synthesis, angiopreventive activity, and in vivo tumor inhibition of novel benzophenone–benzimidazole analogs
Aim The development of anticancer drugs with specific targets is of prime importance in
modern biology. This study investigates the angiopreventive and in vivo tumor inhibition …
modern biology. This study investigates the angiopreventive and in vivo tumor inhibition …
A straightforward synthesis of N-monosubstituted α-keto amides via aerobic benzylic oxidation of amides
J Shao, X Huang, S Wang, B Liu, B Xu - Tetrahedron, 2012 - Elsevier
An efficient sodium bicarbonate promoted aerobic oxidation reaction to prepare N-
monosubstituted α-keto amides in the presence of n-tetrabutylammonium hydrogensulfate …
monosubstituted α-keto amides in the presence of n-tetrabutylammonium hydrogensulfate …