[HTML][HTML] Applications of nanoparticle systems in drug delivery technology
The development of nanoparticle-based drug formulations has yielded the opportunities to
address and treat challenging diseases. Nanoparticles vary in size but are generally ranging …
address and treat challenging diseases. Nanoparticles vary in size but are generally ranging …
[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design
As small molecule drugs become harder to develop and less cost effective for patient use,
efficient strategies for their property improvement become increasingly important to global …
efficient strategies for their property improvement become increasingly important to global …
Role of recombinant DNA technology to improve life
In the past century, the recombinant DNA technology was just an imagination that desirable
characteristics can be improved in the living bodies by controlling the expressions of target …
characteristics can be improved in the living bodies by controlling the expressions of target …
Applied concepts in PBPK modeling: how to build a PBPK/PD model
L Kuepfer, C Niederalt, T Wendl… - CPT …, 2016 - Wiley Online Library
The aim of this tutorial is to introduce the fundamental concepts of physiologically based
pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their …
pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their …
Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development
HM Jones, K Rowland‐Yeo - CPT: pharmacometrics & systems …, 2013 - Wiley Online Library
The aim of this tutorial is to introduce the concept of physiologically based pharmacokinetic
(PBPK) modeling to individuals in the pharmaceutical industry who may be relatively new to …
(PBPK) modeling to individuals in the pharmaceutical industry who may be relatively new to …
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
S Adler, D Basketter, S Creton, O Pelkonen… - Archives of …, 2011 - Springer
The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …
on the market in Europe after 2013. In that context, the European Commission invited …
Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment
High-throughput in vitro toxicity screening can provide an efficient way to identify potential
biological targets for chemicals. However, relying on nominal assay concentrations may …
biological targets for chemicals. However, relying on nominal assay concentrations may …
Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review
Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can
help predict the pharmacokinetics of drugs in humans and evaluate the effects of intrinsic …
help predict the pharmacokinetics of drugs in humans and evaluate the effects of intrinsic …
IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …
transformation from observational to predictive science. New approach methodologies …