Hereditary degenerations of the human retina are genetically heterogeneous, with well over
100 genes implicated so far. This Seminar focuses on the subset of diseases called retinitis …

In the last few years there has been a veritable explosion of knowledge about cyclic
nucleotide phosphodiesterases. In particular, the accumulating data showing that there are …

Purpose.: We noted an unexpected inheritance pattern of lesions in several strains of gene-
manipulated mice with ocular phenotypes. The lesions, which appeared at various stages of …

Light exerts widespread effects on physiology and behaviour. As well as the widely-
appreciated role of light in vision, light also plays a critical role in many non-visual …

The Jackson Laboratory, having the world's largest collection of mouse mutant stocks and
genetically diverse inbred strains, is an ideal place to look for genetically determined eye …

PURPOSE: To characterize ocular abnormalities associated with iris atrophy in DBA/2J mice
and to determine whether mice of this strain develop elevated intraocular pressure (IOP) and …

We report the chromosomal localization, mutant gene identification, ophthalmic appearance,
histology, and functional analysis of two new hereditary mouse models of retinal …

Mutations in the β subunit of the cGMP phosphodiesterase gene (βPDE) can cause a
recessively inherited retinal degeneration in several species, including mice, dogs and …

Cognitive impairment in Down syndrome (DS) is characterized by deficient learning and
memory. Mouse genetic models of DS exhibit impaired cognition in hippocampally mediated …

Fragile‐X syndrome is a common form of mental retardation resulting from the inability to
produce the fragile‐X mental retardation protein. The specific function of this protein is …