Over the last 50 years, the reeler mutant mouse has become an important model for studying
normal and abnormal development in the cerebral cortex and other regions of the brain …

The genetic basis is now known for several disorders of neuronal migration in the
developing cerebral cortex. Identification of the cellular processes mediated by the …

The processing of amyloid precursor protein (APP) to Aβ is an important event in the
pathogenesis of Alzheimer's disease, but the physiological function of APP is not well …

Reelin is a large extracellular protein that controls cortical development. It binds to
lipoprotein receptors very-low-density lipoprotein receptor and apolipoprotein-E receptor …

The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb,
hippocampus, basal ganglia, and amygdala, is the most complex and intricate region of the …

Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

The disrupted cortical lamination phenotype in reeler mice and subsequent identification of
the Reelin signaling pathway have strongly informed models of cortical development. We …

REELIN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in
GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix …

Developmental defects in neuronal positioning and synaptic connectivity are commonly
found in neurological diseases, and they are believed to underlie many cognitive and …

Summary Apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor,
members of the low-density lipoprotein receptor (LDLR) protein family, function as neuronal …