Quantitative mass spectrometry imaging of biological systems

D Unsihuay, D Mesa Sanchez… - Annual review of physical …, 2021 - annualreviews.org
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Spatial metabolomics principles and application to cancer research

M Planque, S Igelmann, AMF Campos… - Current Opinion in …, 2023 - Elsevier
Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics.
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …

Considerations for MALDI-based quantitative mass spectrometry imaging studies

F Tobias, AB Hummon - Journal of proteome research, 2020 - ACS Publications
Significant advances in mass spectrometry imaging (MSI) have pushed the boundaries in
obtaining spatial information and quantification in biological samples. Quantitative MSI …

Spatial pharmacology using mass spectrometry imaging

P Rajbhandari, TV Neelakantan, N Hosny… - Trends in …, 2024 - cell.com
The emerging and powerful field of spatial pharmacology can map the spatial distribution of
drugs and their metabolites, as well as their effects on endogenous biomolecules including …

[HTML][HTML] Mass spectrometry imaging in drug distribution and drug metabolism studies–Principles, applications and perspectives

JR Granborg, AM Handler, C Janfelt - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
New mass spectrometry imaging (MSI) techniques are gaining importance in various stages
of the drug discovery and development chain as well as in more fundamental studies of drug …

Toward omics-scale quantitative mass spectrometry imaging of lipids in brain tissue using a multiclass internal standard mixture

M Vandenbosch, SM Mutuku, MJQ Mantas… - Analytical …, 2023 - ACS Publications
Mass spectrometry imaging (MSI) has accelerated our understanding of lipid metabolism
and spatial distribution in tissues and cells. However, few MSI studies have approached lipid …

What are we imaging? Software tools and experimental strategies for annotation and identification of small molecules in mass spectrometry imaging

G Baquer, L Sementé, T Mahamdi… - Mass Spectrometry …, 2023 - Wiley Online Library
Mass spectrometry imaging (MSI) has become a widespread analytical technique to perform
nonlabeled spatial molecular identification. The Achilles' heel of MSI is the annotation and …

Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging

ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

A critical and concise review of mass spectrometry applied to imaging in drug discovery

RJA Goodwin, Z Takats… - … : Advancing the Science of …, 2020 - journals.sagepub.com
During the past decade, mass spectrometry imaging (MSI) has become a robust and
versatile methodology to support modern pharmaceutical research and development. The …

Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison

L Lamont, D Hadavi, B Viehmann, B Flinders… - Analytical and …, 2021 - Springer
Mass spectrometry imaging (MSI) provides insight into the molecular distribution of a broad
range of compounds and, therefore, is frequently applied in the pharmaceutical industry …