The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many
human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour …

Macroautophagy (autophagy hereafter) captures, degrades, and recycles intracellular
components to maintain metabolic homeostasis and protein and organelle quality control …

Mutations in the TP53 (p53) gene are present in a large fraction of human tumours, which
frequently express mutant p53 proteins at high but heterogeneous levels. The clinical …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

The activities of p53 cover diverse aspects of cell biology, including cell cycle control,
apoptosis, metabolism, fertility, differentiation and cellular reprogramming. Although loss of …

The p53 protein has been extensively studied for its capacity to prevent proliferation of cells
with a damaged genome. Surprisingly, however, our recent analysis of mice expressing a …

Cancers are rare because their evolution is actively restrained by a range of tumour
suppressors. Of these p53 seems unusually crucial as either it or its attendant upstream or …

The tumor suppressor gene TP53 is one of the most frequently mutated genes in human
cancer. The central role of the TP53 protein in several fundamental processes such as …

The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising
drug target for cancer therapy. A key Mdm2 function is to promote ubiquitylation and …

Numerous studies focus on the tumor suppressor p53 as a protector of genomic stability,
mediator of cell cycle arrest and apoptosis, and target of mutation in 50% of all human …