Severely impaired and dysregulated cytochrome P450 expression and activities in hepatocellular carcinoma: implications for personalized treatment in patients
T Yan, L Lu, C Xie, J Chen, X Peng, L Zhu… - Molecular cancer …, 2015 - AACR
This study aims to systematically determine the activities and expressions of cytochrome
P450s (CYP) in hepatocellular carcinoma (HCC) patients to support their optimal use in …
P450s (CYP) in hepatocellular carcinoma (HCC) patients to support their optimal use in …
Associations of antidepressants and antipsychotics with lipid parameters: Do CYP2C19/CYP2D6 genes play a role? A UK population-based study
A Richards-Belle, I Austin-Zimmerman… - Journal of …, 2023 - journals.sagepub.com
Background: Dyslipidaemia is an important cardiovascular risk factor for people with severe
mental illness, contributing to premature mortality. The link between antipsychotics and …
mental illness, contributing to premature mortality. The link between antipsychotics and …
Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and …
Purpose To determine the liver expression of cytochrome P450 (CYPs) and uridine 5'-
diphosphate-glucuronosyltransferases (UGTs), the major phase I and II metabolism …
diphosphate-glucuronosyltransferases (UGTs), the major phase I and II metabolism …
Length of Psychiatric Hospitalization is Correlated With CYP2D6 Functional Status in Inpatients with Major Depressive Disorder
G Ruaño, BL Szarek, D Villagra, K Gorowski… - Biomarkers in …, 2013 - Taylor & Francis
Aim: This study aimed to determine the effect of the CYP2D6 genotype on the length of
hospitalization stay for patients treated for major depressive disorder. Methods: A total of 149 …
hospitalization stay for patients treated for major depressive disorder. Methods: A total of 149 …
The Pain Registry for Epidemiological, Clinical, and Interventional Studies and Innovation (PRECISION): registry overview and protocol for a propensity score …
JC Licciardone, RJ Gatchel, N Phillips… - Journal of pain …, 2018 - Taylor & Francis
Background Low back pain is the leading cause of disability worldwide. Nonsteroidal anti-
inflammatory drugs (NSAIDs) are recommended as the first-line pharmacologic therapy for …
inflammatory drugs (NSAIDs) are recommended as the first-line pharmacologic therapy for …
Results of the CYP-GUIDES randomized controlled trial: Total cohort and primary endpoints
G Ruaño, S Robinson, T Holford, R Mehendru… - Contemporary clinical …, 2020 - Elsevier
Abstract CYP-GUIDES (Cytochrome Psychotropic Genotyping Under Investigation for
Decision Support) is a randomized controlled trial (RCT) comparing 2 outcomes in …
Decision Support) is a randomized controlled trial (RCT) comparing 2 outcomes in …
Computational prognostic evaluation of Alzheimer's drugs from FDA-approved database through structural conformational dynamics and drug repositioning …
472a Wednesday, February 22, 2023 profiles. The possible associations of selected drugs
with AD related genes were predicted by pharmacogenomics analysis and confirmed …
with AD related genes were predicted by pharmacogenomics analysis and confirmed …
Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genes
D Villagra, J Goethe, HI Schwartz, B Szarek… - Biomarkers in …, 2011 - Taylor & Francis
Aims: We aim to demonstrate clinical relevance and utility of four novel drug-metabolism
indices derived from a combinatory (multigene) approach to CYP2C9, CYP2C19 and …
indices derived from a combinatory (multigene) approach to CYP2C9, CYP2C19 and …
Psychological distress and dyslipidemia in Chinese police officers: a 4-year follow-up study in Tianjin, China
X Chen, L Leng, H Yu, X Yang, G Dong… - … of Occupational and …, 2015 - journals.lww.com
Objective: This study aimed at investigating whether psychological distress in police officers
was associated with dyslipidemia. Methods: A survey was conducted to examine the …
was associated with dyslipidemia. Methods: A survey was conducted to examine the …
[HTML][HTML] Sub-Analysis of CYP-GUIDES data: assessing the prevalence and impact of drug-gene interactions in an ethnically diverse cohort of depressed individuals
RD Crutchley, N Keuler - Frontiers in Pharmacology, 2022 - frontiersin.org
Introduction: Minority groups are underrepresented in pharmacogenomics (PGx) research.
Recent sub-analysis of CYP-GUIDES showed reduced length of stay (LOS) in depressed …
Recent sub-analysis of CYP-GUIDES showed reduced length of stay (LOS) in depressed …