Parietal cells are responsible for gastric acid secretion, which aids in the digestion of food,
absorption of minerals, and control of harmful bacteria. However, a fine balance of activators …

The mucosa of the body of the stomach (ie, the gastric corpus) uses 2 overlapping, depth-
dependent mechanisms to respond to injury. Superficial injury heals via surface cells with …

Atrophic gastritis, intestinal metaplasia, and epithelial dysplasia of the stomach are common
and are associated with an increased risk for gastric cancer. In the absence of guidelines …

Autoimmune gastritis is a chronic progressive inflammatory condition that results in the
replacement of the parietal cell mass by atrophic and metaplastic mucosa. A complex …

Background & Aims: A cascade of precursor lesions (eg, atrophic gastritis, intestinal
metaplasia, and dysplasia) precedes most gastric adenocarcinomas. Quantification of …

The association between chronic inflammation and cancer is now well established. This
association has recently received renewed interest with the recognition that microbial …

The discovery of Helicobacter pylori overturned the conventional dogma that the stomach
was a sterile organ and that pH values< 4 were capable of sterilizing the stomach. H. pylori …

Background and aims: A number of Helicobacter pylori outer membrane proteins (OMPs)
undergo phase variations. This study examined the relation between OMP phase variations …

Gastric cancer is the fourth most common malignancy and the second leading cause of
cancer-related death worldwide. 1 Although the incidence of gastric cancer in North America …

Chronic inflammation caused by infection with Helicobacter pylori and autoimmune gastritis
increases an individual's risk of developing gastric cancer. More than 90% of gastric cancers …