Adrenarche is the maturational increase in adrenal androgen production that normally
begins in early childhood. It results from changes in the secretory response to …

Cytochrome P450 oxidoreductase (POR) is an enzyme that is essential for multiple
metabolic processes, chiefly among them are reactions catalyzed by cytochrome P450 …

Context: P450 oxidoreductase deficiency (PORD) is a unique congenital adrenal
hyperplasia variant that manifests with glucocorticoid deficiency, disordered sex …

Cytochrome P450 oxidoreductase (POR) is required for metabolic reactions of steroid and
drug metabolizing cytochrome P450 proteins located in endoplasmic reticulum. Mutations in …

Cytochrome P450 oxidoreductase (POR) supports reactions of microsomal cytochrome
P450 which metabolize drugs and steroid hormones. Mutations in POR cause disorders of …

Context: Only approximately 85% of patients with a clinical diagnosis complete androgen
insensitivity syndrome and less than 30% with partial androgen insensitivity syndrome can …

Sex development is a very complex biological event that requires the concerted
collaboration of a large network of genes in a spatial and temporal correct fashion. In the …

Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting
steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches …

Abstract Context Steroidogenic factor 1 (NR5A1/SF-1) is a nuclear receptor that regulates
sex development, steroidogenesis and reproduction. Genetic variants in NR5A1/SF-1 are …

DNA binding as well as ligand binding by nuclear receptors has been studied extensively.
Both binding functions are attributed to isolated domains of which the structure is known …