Recent advances in microscale electroporation

SE Choi, H Khoo, SC Hur - Chemical reviews, 2022 - ACS Publications
Electroporation (EP) is a commonly used strategy to increase cell permeability for
intracellular cargo delivery or irreversible cell membrane disruption using electric fields. In …

An atlas of nano-enabled neural interfaces

H Acarón Ledesma, X Li, JL Carvalho-de-Souza… - Nature …, 2019 - nature.com
Advances in microscopy and molecular strategies have allowed researchers to gain insight
into the intricate organization of the mammalian brain and the roles that neurons play in …

Targeted extracellular vesicle delivery systems employing superparamagnetic iron oxide nanoparticles

Z Zhuo, J Wang, Y Luo, R Zeng, C Zhang, W Zhou… - Acta biomaterialia, 2021 - Elsevier
In the past decade, the study of extracellular vesicles (EVs), especially exosomes (50–150
nm) have attracted growing interest in numerous areas of cancer and tissue regeneration …

Bulk electroporation for intracellular delivery directly driven by mechanical stimulus

F Liu, Z Yang, R Yao, H Li, J Cheng, M Guo - ACS nano, 2022 - ACS Publications
Electroporation (EP) is an effective and widely accepted intracellular delivery method for
fundamental research and medical applications. Existing electroporation methods usually …

[HTML][HTML] In situ sensors for blood-brain barrier (BBB) on a chip

Y Liang, JY Yoon - Sensors and Actuators Reports, 2021 - Elsevier
The blood-brain barrier (BBB) is critical for the central nervous system, as its integrity
protects neurons and other brain cells from harmful toxicants and disease-associated …

Electrotherapies for glioblastoma

EPW Jenkins, A Finch, M Gerigk, IF Triantis… - Advanced …, 2021 - Wiley Online Library
Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

Dynamic 3D on-chip BBB model design, development, and applications in neurological diseases

X Chen, C Liu, L Muok, C Zeng, Y Li - Cells, 2021 - mdpi.com
The blood–brain barrier (BBB) is a vital structure for maintaining homeostasis between the
blood and the brain in the central nervous system (CNS). Biomolecule exchange, ion …

New potential strategies for Alzheimer's disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9

E Sánchez-López, M Ettcheto, MA Egea… - … , Biology and Medicine, 2017 - Elsevier
Dexibuprofen loaded pegylated poly (lactic-co-glycolic) nanospheres prepared by solvent
diffusion method were designed to increase Dexibuprofen brain delivery reducing systemic …

Tumor-derived extracellular vesicles disrupt the blood–brain barrier endothelium following high-frequency irreversible electroporation

KR Murphy, KN Aycock, S Marsh, AN Hay… - Scientific Reports, 2024 - nature.com
High-frequency irreversible electroporation (H-FIRE), a nonthermal brain tumor ablation
therapeutic, generates a central tumor ablation zone while transiently disrupting the …

Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma

PA Garcia, B Kos, JH Rossmeisl Jr, D Pavliha… - Medical …, 2017 - Wiley Online Library
Purpose Irreversible electroporation (IRE) has been developed as a promising minimally
invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine …