BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Preservation of gonadal function is an important priority for the long-term health of cancer
survivors of both sexes and all ages at treatment. Loss of opportunity for fertility is a prime …

Testicular tissue cryopreservation is an experimental method to preserve the fertility of
prepubertal patients before they initiate gonadotoxic therapies for cancer or other conditions …

Patients preparing to undergo gonadotoxic medical therapy, radiation therapy, or
gonadectomy should be provided with prompt counseling regarding available options for …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

Estimates suggest that by 2010, one in 715 people in the UK will have survived cancer
during childhood. With increasing numbers of children cured, attention has focused on their …

This article will provide an updated review of spermatogonial stem cells and their role in
maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial …

Normal spermatogenesis is essential for reproduction and depends on proper
spermatogonial stem cell (SSC) function. Genes and signaling pathways that regulate SSC …

During the last half of the 20th century there have been considerable advancements in
mammalian reproductive technologies, including in vitro production of pre-implantation …

Starting from the period of testis differentiation, the Sertoli cell plays a pivotal role in the
development of a functional testis. FSH is the major mitotic factor for Sertoli cells. Because …