Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Individuals with diabetes mellitus (DM) disclose a higher incidence and a poorer prognosis
of heart failure (HF) than non-diabetic people, even in the absence of other HF risk factors …

Type 2 diabetes mellitus (T2DM), one of the main types of Noncommunicable diseases
(NCDs), is a systemic inflammatory disease characterized by dysfunctional pancreatic β …

Diabetes is a major risk factor for the development of cardiovascular disease via contributing
and/or triggering significant cellular signaling and metabolic and structural alterations at the …

Diabetes and Alzheimer's disease are common chronic illnesses in the United States and
lack clearly demonstrated therapeutics. Mitochondria, the “powerhouse of the cell”, is …

Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …

ER protein homeostasis (proteostasis) is essential for proper folding and maturation of
proteins in the secretory pathway. Loss of ER proteostasis can lead to the accumulation of …

Cancer cells rely on heightened protein quality control mechanisms, including the ubiquitin-
proteosome system that is predominantly driven by ubiquitination comprising E1, E2, and E3 …

Cardiovascular diseases are currently the primary cause of mortality in the whole world.
Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are …

A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent.
Its underlying mechanisms of berberine against breast carcinoma under hypoxia have not …